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The essential function of CARD9 in diet-induced inflammation and metabolic disorders in mice.
Zeng X, Du X, Zhang J, Jiang S, Liu J, Xie Y, Shan W, He G, Sun Q, Zhao J. Zeng X, et al. J Cell Mol Med. 2018 Jun;22(6):2993-3004. doi: 10.1111/jcmm.13494. Epub 2018 Mar 25. J Cell Mol Med. 2018. PMID: 29575791 Free PMC article.
The results showed that HFD-induced insulin resistance and impairment of glucose tolerance were more severe in WT mice than that in the CARD9(-/-) mice. CARD9 absence significantly modified O(2) consumption, CO(2) production and heat production. ...HFD induced the i …
The results showed that HFD-induced insulin resistance and impairment of glucose tolerance were more severe in WT mice than that in the C …
Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion.
Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X, Du J. Ren J, et al. Am J Hypertens. 2011 Jun;24(6):701-7. doi: 10.1038/ajh.2011.42. Epub 2011 Mar 24. Am J Hypertens. 2011. PMID: 21436792 Free PMC article.
METHODS: Two-month-old CARD9-deficient (CARD9(-/-)) and wild-type (WT) male mice were infused with Ang II (1,500 ng/kg/min) or saline for 7 days. ...RESULTS: WT mice with Ang II infusion showed a marked increase in CARD9(+) macrophages in the heart, but CA …
METHODS: Two-month-old CARD9-deficient (CARD9(-/-)) and wild-type (WT) male mice were infused with Ang II (1,500 ng/kg/min) or …